Defective Autophagy Initiates Malignant Transformation
نویسندگان
چکیده
منابع مشابه
Autophagy in malignant transformation and cancer progression.
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic respo...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2016
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2016.05.001